GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7552404 | 1 | rs4559448 | chr1:76203456 | ACADM | chr1:76190043-76229353:+ | 0.13 | 3.69 | 0.000254 | Blood metabolite levels;Acylcarnitine levels |
| THCA | cis | rs7552404 | 1 | rs4559448 | chr1:76203456 | MSH4 | chr1:76262630-76378923:+ | 0.24 | 4.03 | 6.58E-5 | Blood metabolite levels;Acylcarnitine levels |
| THCA | cis | rs7714584 | 1 | rs4560537 | chr5:150262586 | LOC134466 | chr5:150310000-150326146:- | 0.38 | 5.4 | 1.04E-7 | Crohn's disease |
| THCA | cis | rs12134663 | 1 | rs45608437 | chr1:11857926 | MTHFR | chr1:11845787-11866115:- | 0.23 | 3.64 | 0.000304 | Homocysteine levels |
| THCA | cis | rs6477998 | 1 | rs4560868 | chr9:115985499 | ALAD | chr9:116148593-116163618:- | -0.14 | -3.49 | 0.000521 | Hematology traits |
| THCA | cis | rs6477998 | 1 | rs4560868 | chr9:115985499 | BSPRY | chr9:116111812-116133512:+ | -0.12 | -3.62 | 0.000323 | Hematology traits |
| THCA | cis | rs6477998 | 1 | rs4560868 | chr9:115985499 | CDC26 | chr9:116029290-116037869:- | 0.49 | 11.11 | 1.17E-25 | Hematology traits |
| THCA | cis | rs6477998 | 1 | rs4560868 | chr9:115985499 | PRPF4 | chr9:116037974-116055054:+ | -0.19 | -4.61 | 5.06E-6 | Hematology traits |
| THCA | cis | rs12780845 | 1 | rs45615636 | chr10:17210591 | TRDMT1 | chr10:17184983-17243681:- | -0.44 | -10.18 | 3.77E-22 | Homocysteine levels |
| THCA | cis | rs12780845 | 1 | rs45615636 | chr10:17210591 | VIM | chr10:17270258-17279592:+ | -0.18 | -3.36 | 0.00085 | Homocysteine levels |
| THCA | cis | rs7178424 | 1 | rs4564516 | chr15:62365107 | VPS13C | chr15:62144592-62352647:- | -0.11 | -4.12 | 4.5E-5 | Height |
| THCA | cis | rs2613514 | 1 | rs4564643 | chr17:76077894 | TMC6 | chr17:76108999-76128488:- | 0.21 | 3.93 | 9.56E-5 | Thiazide-induced adverse metabolic effects in hypertensive patients |
| THCA | cis | rs9790314 | 1 | rs456611 | chr3:161097268 | NMD3 | chr3:160939099-160971319:+ | -0.1 | -3.37 | 0.000801 | Morning vs. evening chronotype |
| THCA | cis | rs4493873 | 1 | rs4568579 | chr8:92072144 | LRRC69 | chr8:92114847-92231464:+ | -0.23 | -3.71 | 0.000231 | Migraine - clinic-based |
| THCA | cis | rs7216064 | 1 | rs4569324 | chr17:65872750 | C17orf58 | chr17:65987218-65989765:- | 0.2 | 3.97 | 8.17E-5 | Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma |